オオシロ サトル
  大城 聰   スポーツ・健康科学部 健康科学科   教授
■ 標題
  Relation between physical and mental fatigue in urine biomarker, hydorgen peroxide.
■ 概要
  Oxidative stress is associated with fatigue. Therefore, biomarkers for oxidative stress may be available for those to fatigue. Bomarkers for oxidative stress have been found in serum, urine and brain; 8-hydoxy-deoxyguanosine(a marker for oxidative damage DNA) , L-carnitine, some oxidative stress biomarkers, isoprostane, TBARS, protein carbonyls, catalase, glutathione peroxidase, and oxidized glutathione (GSSG), reduced glutathione GSH, etc. However, whether biomarkers for oxidative stress are useful for those to fatigue, furthermore, relation between physical and mental fatigue in biomarkers is unknown. in the present study, we examined whether hydrogen peroxide (H2O2) is useful for biomarkers for physical and/or mental fatigue using urine from miceand rats after treatment physical and mental stress. We are also going to examine relation between physical and mental fatigue in biomarker for mental fatigue by RT-PCR and Western blot analysis in brain. This study (No.22500614) isupproted by Grant-in-Aid for Scientific Research(KAKENHI); Grant-in-Aid for Scientific Research (C) in 2010 and 2011.
  Oshiro,S., Morioka, M.S., Iwasawa, Y., Ueda, Y., Ren, J., Yanase, S. and Takayama, S.
  共著   Journal of Neurochemistry   Wiley-Blackwell   118(Suppl.),pp.239-240   2011/08


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