オオシロ サトル
  大城 聰   スポーツ・健康科学部 健康科学科   教授
■ 標題
  Dysregulation of Iron Metabolism in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Screlosis
■ 概要
  Dysregulation iron metabolism has been observed in patients with neurodegenerative disease (NDs). Utilization of several importers and exporteres for rtranport in brain cells helps maintain iron homeostasis. Dysregulation of iron homeostasis leads to the production of neurotoxic substances and reactive oxygen species, resulting in iron-induced oxidative stress. In Alzheimer's disease (AD) and Parkinson's disease (PD), circumstances evidence has shown that dysregulation of brain iron homeostasis leads to abnormal iron accumulation. Several genetic stidies have revealed mutaions in genes associated with increased iron uptake, increased oxidaitive stress, and an altered inflammatory response in amyotrophic lateral sclerosis (ALS). Here, we review the recent findings on brain iron meatbolism in common NDs, such as AD, PD and ALS. We also summarize the conventional and novel types of iron chelators, which can successfully decrease excess iron accumulation in brain lesions. For example, iron-chelating drugs have neuroprotective effects, preventing neural apoptosis and activate cellular protective pathways against oxidative stress. Glial cells also protect neurons by secreting antioxidants and anti-apoptotic substances. These new findings of experimental and clinical studies may provide a scientific foundation for advances in drug development for NDs.
  Satoru Oshiro, Masaki S. Moriok and Masataka Kikuchi.
  共著   Advances in Pharmacological Sciences   Hindawi Publishing Corp.   2011(2011),pp.378278.Epub 2011   2011/10


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